Suggested Level of Knowlege: Detailed

LOs

SS_PA 1.51 Describe how the pharmacokinetics of drugs commonly used in anaesthesia in neonates and children differ from adults and the implications for anaesthesia

SS_PA 1.53 Describe the changes in the pharmacodynamics of volatile agents, analgesics, opioids and neuromuscular blocking agents in the neonate and the changes that occur with growth and development and the implications for anaesthesia

SS_PA 1.79 Describe the maximum safe doses of local anaesthetic agents in different age groups

SS_PA 1.78 Describe the difference in pharmacokinetics of local anaesthetic agents in neonates and children from adults and the implications for regional blockade

Past SAQs

2008.2 Outline how the pharmacokinetics of morphine, bupivacaine and suxamethonium differ in the neonate compared to the adult. Briefly describe the clinical implications of these differences.

2003.2 Outline the pharmacological differences beween neonates and adults with reference to sevoflurane, vecuronium and morphine.

Drug Variability in Paediatrics